HORDB

ID: hor005396
Uniprot ID: P01338
Protein name: Insulin A chain
Gene name: ins2
Organism: Batrachoididae sp. (Toadfish)
Family: insulin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: unclassified Batrachoididae, Batrachoididae (family), Batrachoidiformes (order), Batrachoidaria, Percomorphaceae, Euacanthomorphacea, Acanthomorphata, Ctenosquamata, Eurypterygia, Neoteleostei, Euteleosteomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0005975 carbohydrate metabolic process; GO:0006006 glucose metabolic process; GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region

Function: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005396_AF2.pdb

hor005396_ESM.pdb

Mass:	281572	Formula:	C102H156N30O33S4
Absent amino acids:	AMTW	Common amino acids:	C
pI:	5.51	Basic residues:	3
Polar residues:	8	Hydrophobic residues:	4
Hydrophobicity:	-54.29	Boman Index:	-4772
Half-Life:	30 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	50.95
Instability Index:	7557.62	Extinction Coefficient cystines:	1740
Absorbance 280nm:	87